A patient-specific intracranial aneurysm model

Abstract: objective to establish an in vitro model for the study of complex biological effects

Flow stress of three-endothelial cellsdimensional (3D)patient-

Specific vascular geometry.

Materials and methods using 3D printing technology, in the blood vessel image data obtained from rotating angiography, blood vessel reproductions were made with polygenadiosilone.

The vascular model is coated with a fiber-connected protein, immersed in a tube filled with suspended matter of endothelial cells, and then cultured at slow rotation in three dimensions.

With the model of internal skin vascular, the medium with viscosity was filled in the circulation.

Computational fluid dynamics (CFD)

The study was conducted using the perfusion conditions used in the flow experiment.

The morphology of endothelial cells was observed under a co-focused microscope.

Results CFD studies showed low wall shear stress and circulating flow at the top of the basal tip aneurysm, and linear flow of the parent artery.

Co-focused imaging showed uniform coverage of single-layer endothelial cells on the inner surface of the vascular model.

After 24 hours of circulation of blood flow, the endothelial cells of the mother artery were spindle-like and aligned with the direction of blood flow.

In contrast, the shape and size of the endothelial cells at the tip of the aneurysm are irregular.

Conclusion a geometric model with a living endothelial liner was successfully established.

This in vitro model enables a new research method to combine the study of the biological effects of complex flows on endothelial cells with CFD analysis and patient information, including the presence of the growth or rupture of an aneurysm.

Objective to establish an in vitro model for the study of complex biological effects

Flow stress of three-endothelial cellsdimensional (3D)patient-

Specific vascular geometry.

Materials and methods using 3D printing technology, in the blood vessel image data obtained from rotating angiography, blood vessel reproductions were made with polygenadiosilone.

The vascular model is coated with a fiber-connected protein, immersed in a tube filled with suspended matter of endothelial cells, and then cultured at slow rotation in three dimensions.

With the model of internal skin vascular, the medium with viscosity was filled in the circulation.

Computational fluid dynamics (CFD)

The study was conducted using the perfusion conditions used in the flow experiment.

The morphology of endothelial cells was observed under a co-focused microscope.

Results CFD studies showed low wall shear stress and circulating flow at the top of the basal tip aneurysm, and linear flow of the parent artery.

Co-focused imaging showed uniform coverage of single-layer endothelial cells on the inner surface of the vascular model.

After 24 hours of circulation of blood flow, the endothelial cells of the mother artery were spindle-like and aligned with the direction of blood flow.

In contrast, the shape and size of the endothelial cells at the tip of the aneurysm are irregular.

Conclusion a geometric model with a living endothelial liner was successfully established.

This in vitro model enables a new research method to combine the study of the biological effects of complex flows on endothelial cells with CFD analysis and patient information, including the presence of the growth or rupture of an aneurysm.

Footnote author NK: concepts of research, design and development, acquisition and analysis of data, writing of articles.

TM, EW: The development of research.

KN: acquisition of data.

KK: critical review of the article.

Fund KAKENHI (Grants-

Auxiliary for scientific research)

From the Japan Association for the Promotion of Science (JSPS), grant no.

Youth Fellows Award for NK and Jichi Medical University 15k1978, NK 2015.

No one declared a competitive interest.

Patients agreed to the study, including the use of patient image data, with approval from the Institutional Review Committee, which abandoned the patient's request for informed consent.

Review Committee of ethics approval body.

Uncommissioned source and peer review;

External peer review.

Any technical details of the data sharing declaration about model creation and results can be obtained from the corresponding author.

need huge investment, so it is important to shop with caution.
Finding the best products has been made easier, at Shenzhen Tuowei Model Technologies Co., Ltd.. Here you can see completed ranges of produced with advanced equipment and strict quality control. Go to Tuowei Model and send your enquiry if you have any question.
More than half of customers said they have faith with Shenzhen Tuowei Model Technologies Co., Ltd. and abs cnc machining prototype.
abs prototype for automobile abs rapid prototype is one of the most commonly used tool for abs rapid prototyping online.
Shenzhen Tuowei Model Technologies Co., Ltd., which contributes itself on ABS Prototype for creating more useful application.