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breathtaking! the artificial lungs for human transplants made of tobacco

by:Tuowei     2019-08-13
Scientists are developing artificial lungs for human transplant
The most important thing is the use of tobacco.
This unlikely material is modified to produce a synthetic form of collagen, which constitutes a \"scaffold\" for many major organs \".
Researchers have found a way to genetically transform tobacco to produce a large amount of collagen that is almost the same as the human body.
This becomes an \"ink\" and loads into a 3D printer that produces humans
The lungs are made by copying collagen one layer after another.
Then vaccinate the lungs with the patient\'s own stem cells (
Extract from skin samples)
They were cultured into healthy lung tissue suitable for transplant.
Scientists hope the technology
Very early stage.
Can be used for mass
The production of artificial lungs, so that patients who need to be transplanted do not have to wait for a few more months, or even a few years, to obtain a suitable donor organ.
This may mean that it is this plant that causes the death of millions of people through smoking --
On the contrary, related diseases can be used to save lives.
It turns out that tobacco is an ideal tool for growing collagen with the rapid maturity of plants
Just eight weeks.
Therefore, the supply of artificial lungs is sustained.
According to the latest data from NHS Blood and Transplant, the number of people waiting for lung transplants in the UK has risen by 46 age points over the past five years to 354, up from 242 in 2013.
It is believed that the improvement of trauma care has improved the survival rate of accident victims (
So reduce donations);
These figures may also reflect an increase in the number of referrals for lung transplants as awareness of these benefits increases.
Waiting an average of 233 days for lung transplant;
Every four people died before the transplant.
But tobacco
One day, a lung-based lung may be a viable option.
Collagen molecules are tightly bound together to form a firm chain as a supporting structure for cell growth.
There are dozens of different types, some of which are stronger in weight than steel.
The doctor has used collagen in wound dressings and skin grafts to provide a grid
Like the framework of new cells.
But it must be taken from bodies or animals.
Donated human tissue can be rejected by the recipient\'s immune system, while animal tissue is always at risk (however small)
Viruses or bacteria that span species
Scientists at Israeli biotechnology company CollPlant have perfected the way to grow collagen in tobacco plants in just eight weeks.
They take seedlings and add five human genes that are essential to collagen production.
When the plant matures, the leaves are harvested and processed into a purified collagen extract \"bioink \". Now, a U. S.
The joint treatment company is building a 3D-
A printer capable of making artificial lungs using ink.
This printer has been used to make the retina of the human skin, even the eyes, but these are relatively small thin tissues.
Printing a more complex organ requires a custom machine that is also able to cope with large molecules of collagen.
The prototype of the United treatment company uses stereo molding technology in which UV laser irradiation of tobacco
Collagen with the growth of photosensitive molecules.
When light shines on collagen, it becomes solid.
So far, the company has produced only a small fraction of the lung tissue.
Including part of the trachea (windpipe)
And two lungs from it to the lungs.
The length of the paper towel is only a few inches.
The researchers have not yet coated it with stem cells that produce healthy tissue ready to be transplanted to develop it into a functioning human lung.
However, animal experiments have shown that this process is feasible.
Earlier this year, scientists at Harvard University stripped the pig\'s lung cells with detergent and filled them with billions of human stem cells extracted from cord blood.
Results published in the surgical yearbook show that when the new lung is re-connected with the pig\'s circulation, the resulting organs operate like healthy lungs.
But the technology is not without risk.
In 2008, scientists from the Karolinska Institute in Sweden implanted eight people with lung cancer --
Later, six people died when the plastic material used was inhaled by bacteria and virus infection.
Professor Brendon Noble, chief science officer of the UK Stem Cell Foundation, said tobacco
The growing lung has the potential to alter transplant surgery and may be on the market within ten years.
But there is still a long way to go, he added.
There are many challenges to overcome.
It is not clear whether this rather simple method of cell in a \"scaffold\" can be used to construct complex and large structures such as lungs.
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